Oral manifestations of HIV infection are diverse and not still not completely studied. HIV-associated diseases can occur as the first symptoms of infection, these are characterized by high frequency, clinical polymorphism and pronounced course. Periodontal aspects are also neglected in the literature. No papers on the condition of different areas of the oral mucosa, tongue and periodontium where they were studied simultaneously and according to various criteria have been found in the available literature. The objective of the research is to evaluate the condition of periodontium and the oral mucosa in different parts of the oral cavity in HIV-positive patients. Total number of the HIV-positive patients observed was 90, among them 81 males and 9 females between the age range of 24-62. An average age of the patients was 45.2±8.34, with male patients prevailing (p less then 0.001). HIV infection was diagnosed by Western-blot reaction. Clinical examination as well as probing and determination of the pocket depth by means of the periodontal probe was carried out to assess the health status of the oral cavity. Periodontal indices were also determined. It has been found that immunocompromised condition due to HIV infection contributes to the oral mucosa lesions. Namely, coated tongue was observed in 100% of cases, the oral mucosa relief impairment was seen in 75.6% of cases, lip cracks of different location and bright red color of the mucous membrane were observed in 73.3% and 82.2%, respectively (р less then 0.001). Examination of the tongue revealed the symptoms which were not found in the control group, such as tongue coating - in 100% (90 patients observed), epithelial desquamation foci - in 54.4% (49) (p less then 0.001). Inflammatory diseases of periodontium, particularly catarrhal and hypertrophic gingivitis and periodontitis of moderate severity were also revealed.Objective - to study the species composition of microflora and its sensitivity in patients with odontogenic maxillary sinusitis. The study included 230 patients of both sexes aged 18 to 70 years, who were treated at the Moscow Regional Scientifics Research and Clinical Institute named after M. F. Vladimirsky with a diagnosis of Odontogenic maxillary sinusitis. https://www.selleckchem.com/products/ziritaxestat.html Of these, there were 155 patients with odontogenic sinusitis, complicated by perforation of the maxillary sinus and the presence of an oro-antral fistula, and 75 patients with maxillary aspergillosis. All patients underwent microbiological examination of smears and flushes from the maxillary sinus cavity with the determination of the species composition and antibiotic sensitivity. In the majority of the patients with perforative forms of odontogenic maxillary sinusitis, coccal flora (streptococci and various species) was detected, in a smaller number compared to it - facultative and obligate anaerobes, pathogenic fungi (Candida). A comparative analysis of the microflora, depending on the duration of the maxillary sinus perforation, showed that the rhinogenic microorganisms (Moraxella spp.) were found only in intraoperative perforations (up to 20% of cases). The presence of obligate anaerobes (Fusobacterium spp. Bacteroides spp.) was typical for long-existing perforations. In patients with maxillary aspergillosis facultative and obligate anaerobes were found less frequently and in a smaller variety than in patients with perforative maxillary sinusitis. There were no cases of sinus contamination by pathogenic fungi of the genus Candida in this group. At the same time, rhinogenic microgranisms (Moraxella spp.) were detected with a higher frequency (up to 27.3%) in this group of patients.The function of the outer hair cells (OHC) in patients with euthyroid autoimmune thyroiditis (AIT) was investigated in frequency range of 1000 - 8000 Hz. Our aim was to measured of AIT factors influence on auditory function in patients with no subjective sensations of hearing loss. For this study we selected patients with euthyroid AIT. Patients average age on 33,25±6,32 years. The main group consisted of 59 people. The control group was presented by 29 relatively healthy individuals, without AIT and normal hearing function. Each patient was determined the levels of thyroid stimulating hormone (TSH), free thyroxine (T4), free triiodothyronine (T3), thyroid peroxidase antibodies (TPAb), thyroglobulin antibodies (TGAb). The function of OHC of the inner ear was assessed by the registration of distortion product otoacoustic emission (DPOAE) and auditory brainstrem response (ABR) evaluation. We estimated dependency of DPOAE data on TPAb and TGAb levels in the patients' blood tests. We used program Statistical Package for the Social Sciences 17 for statistical data. In the study of dependency between DPOAE and ABR`s data and TPAb, TGAb levels we indicated a statistically significant correlation between increased activity of autoimmune process and decrease OHC function in the frequency range of 5714 - 8000 Hz.The aim of the study was to explore different treatment approaches for degenerative-dystrophic damage of the spine and define the most effective treatment methods, their stages regarding the pathogenetic basis of pain syndromes. Diverse treatments for degenerative-dystrophic damage of the spine do not facilitate but even complicate general practitioner's work due to the fact that information on clinical benefits of various drugs and techniques as well as various types of surgery is too contradictory; there is no single method of consistent combined therapy for vertebrogenic pain. There is no universal therapy or surgery that would provide sustainable relief of symptoms of nonspecific back pain and/or radicular syndrome. The pathogenesis of specific clinical manifestations of the disease and the ratio of clinical manifestations and pathomorphological changes are crucial in choosing the treatment. The general principles of treatment are unchanged rest, analgesics and movement should be combined in appropriate sssues as well as the nerve root regardless of its compression or irritation. Only after the ineffectiveness of NSAIDs and puncture treatments as well as epidural injection and in cases of persistent mechanical compression of the nerve roots taking into account the clinical manifestations, appropriate surgical treatments, both minimally invasive and open, are necessary.